Need insight on lab results?
My biggest concern is lymphoma. I am being seen by my primary, and endocrinologist due to a thyroid nodule, and a neurologist. I’m trying to educate myself to help find answers. I’ve tried researching elevated B12 and the only things I could find said either Hepatitis or some cancers. My Hep tests (and liver enzymes) are negative/normal ranges. These labs were ordered by my neurologist because I currently have an Idiopathic Autonomic Nervous System Disorder due to sensory loss in feet and ankles according to him. (I won’t see him till after first of year) Other symptoms are low BP; bad itchy skin – lower legs, behind knees, perimeter of armpits year round, rest of torso in winter months, loss of appetite, fatigue, pain beneath/behind collarbones (for @ 6 months). Also have a solid nodule (was complex until after FNA) on thyroid along with smaller cystic nodules. Do not have Hashimoto’s antibodies. Have had an enlarged inguinal lymph – right side – for over 1 year, and for at least a week, enlarged lymph node right side – above voice box and under tongue.
There are some from 3 months ago listed for comparison reasons.
Test – 9/26/08 – 12/02/08 (ref value)
WBC – 9.32 – 8.4 (4.0-11.0 k/uL)
RBC – 4.49 – 4.59 (4.2-5.4 M/uL)
HGB – 14.4 – 15.1 (12.0-16.0 g/dL)
HCT – 43.1 – 44.1 (37-47%)
MCV – 96.0 – 96.1 (80-100 fL)
MCH – 32.1 – 32.9 (27-34 pG)
MCHC – 33.4 – 34.2 (32-36 g/dL)
PLT – 243 – 235 (150-400 k/uL)
RDW-CV -12.4 – 12.6 (11.7-15.0%)
MPV – 10.9 – 11.6 (H) (7.3-11.1 fL)
Neutrophil 63.1 – 58.7 (40-70%)
Abs Neutrophil 5.88 – 9.93 (1.8-7.7 K/uL)
Lymphocyte 23.5 – 28.6 (22-44%)
Abs Lymphocyte 2.19 – 2.40 (1.0-4.0 k/uL)
Monocyte 9.5 (H) – 7.9 (H) (0-7.0%)
Abs Monocyte 0.89 (H) – .66 (0-.08 K/uL)
Eosinophil 2.9 – 3.8 (0-4%)
Abs Eosinophil .27 – .32 (0-0.4 k/uL)
Basophil 1.0 – 1.0 (0-1%)
Abs Basophil .09 – .08 (0-0.2 K/uL)
Misc Labs 12/08 for reference
ANA by EIA – 1.7 (H) (low: <1.5 OD)
(Anti-SM, Anti-RNP, Anti-SSA, Anti-SSB, Anti-Jo-1, Anti-SCL-70 – all negative)
Vitamin B12 – 710 (H) (221-700pg/mL)
Hep B Core Ab, total – Neg
Hep C Antibody IA – Neg
HBsAg – Neg
HepB Surface Ab Qual – Neg
HIV 1 & 2 Ab EIA – Non Reactive
There is a high incident of cancer in my family.
Father’s side:
My grandfather and 4 of his brothers had cancer.
GF – prostate, Gr.Unc.1 – Thyroid, GU2 – bladder, GU3 – prostate
Reason to believe Great Grandfather had cancer as well. He committed suicied in 1928 due to "health reasons"
Cousin – recently passed away from an aggressive leukimia
Mother’s side:
Mother has CLL, also a breast cancer survivor, Great Grandmother – stomach cancer.
Would appreciate any insight into all this.
I tried answering the responses, and this is the only way I found to do it. Don’t know the ages of diagnosis, other than my mother. Both CLL and Breast Cancer were under 50 years old. I mention lymphoma because of the thyroid nodule. According to the National Cancer Society – because we have a family member that had a thyroid cancer, and because my father also has a multi-nodular goiter – I am at an increased risk of developing thyroid lymphoma. If the nodes don’t go down by the time I see my neuro for follow up – I will ask about biopsy. From what I understand, that is the only true way to test for lymphoma. I will be getting tested this coming Monday – EMG, QSRT, Tilt table and skin biopsies (looking for nerve damage).My sister also has a low BP problem, and mine has been like this for a few years – regardless of my fluid and salt intake. That is in part why the neuro tests.
Auto-immune disorders also run high on dad’s side, including me – I have morphea scleroderma.
Thank you!
Hi,
The high B12 is barely high, if you are taking multivitamins this could cause this.
Almost all of your labs are normal, your monocyte % and absolute are a bit high, this can be from a number of reasons. The fact that you have multiple enlarged lymph nodes, you may want to ask your primary physician about getting these possibly biopsied to rule out any malignancies. I have included a website that I recommend to everyone and use it when I need to do quick research at work.
Hope this helps.
NS – Clinical Lab Scientist
Popularity: 1% [?]
September 28th, 2009 at 1:18 am
Hi,
The high B12 is barely high, if you are taking multivitamins this could cause this.
Almost all of your labs are normal, your monocyte % and absolute are a bit high, this can be from a number of reasons. The fact that you have multiple enlarged lymph nodes, you may want to ask your primary physician about getting these possibly biopsied to rule out any malignancies. I have included a website that I recommend to everyone and use it when I need to do quick research at work.
Hope this helps.
NS – Clinical Lab Scientist
References :
http://www.labtestsonline.org/
September 28th, 2009 at 1:26 am
I can’t help you with the lab results, but I can give you some reassurance about your family history. It doesn’t appear based on this that you are at any greater risk of cancer than someone with no family history of cancer.
Hereditary cancer is rare – fewer than 10% of all cancer cases are hereditary.
A sign that cancer MAY be hereditary within a family is when several members of the same side of the family have had the SAME type of cancer, especially if some developed it at a younger than usual age. In those circumstances it may be considered appropriate to investigate the possibility of an inherited faulty cancer gene.
Even if a faulty cancer gene is detected, not all family members will necessarily inherit it and inheriting it does not mean a person will definitely get that cancer.
Several family members having different types of cancer is NOT a sign of hereditary cancer, and as this is the case in your family then you are unlikely to be at any increased risk.
You don’t say how old your family members were at diagnosis, though some of the types of cancer – prostate for example – suggests that some of them were elderly. Cancer that is diagnosed after the age of 50 is less likely to be hereditary.
With at least one in three people developing cancer, it isn’t unusual for several members of the same family to have had non-hereditary cancer.
This is the case in my family; several members of my family have had cancer, including two of my grandparents and both my parents. All but one died of it. None of their cancers were hereditary and no members of my immediate or extended family have ever been considered at increased risk of them.
Of my parents’ six children, now aged between 47 and 60, only I have developed cancer and mine too is non-hereditary and unrelated to theirs.
References :
September 28th, 2009 at 2:12 am
There is basically nothing on your labs of any significance. Your monocytes are moving closer to the normal range and a mildly elevated B-12 level may also not be significant. I am not a doctor but with lower blood pressures there are usually 2 causes – if you are on blood pressure medication, that needs to be adjusted; the other reason is mild dehydration which can give you several of your symptoms. You might try dramatically increasing your water intake daily and see if this resolves a couple of your problems (low BP and dry itchy skin). Other than these basic suggestions, doctors are going to have to figure out what is going on. Your symptoms are too numerous for a common lay person to speculate on and it is rare that any doctors have time during a weekday to peruse Yahoo! answers.
References :
Health care provider